I have a PB G4, and no problems yet. Cleardock, Detour (no customisations yet), Shapeshifter, and Slider are all doing okay. I tested LabelsX and WindowShadeX, and it ran their demos just fine.

Note that Apple will not support any system with APE installed - reason enough to stay away from it as a user. Developers note: you are limiting your user community to those who do not need any support from Apple.

Been using it for WindowShadeX and ClearDock, along with a couple other ones that come and go as I need them.
Highly recommended. I've never had a single problem with it (PBG4), and no noticeable slowdown at all. Fantastic app.

If your Rosetta problems happen still even with the new update, try entering this into Terminal.

sudo killall translated

I use it all of the time for LabelsX, Fruitmenu, Cleardock, Windowshade X, Shapeshifter, and for Instant Hijack Server (for AudioHijack Pro) all on a Macbook Pro and before that on a Powerbook. However there have been a few problems with Rosetta applications not starting up since I started using APE with the MBP. The problems, though, have not been so bad that I've been willing to give up using Fruitmenu for more than a few days. I gues you can say that I'm kind of addicted to APE.

I use it to Run WindowShadeX under 10.4.8 - no problems to date.

I use it because I run Shapeshifter and ClearDock.

APE is very, very bad. Stay as far away from APE as you can. You OS will thank you.