FontNuke is a utility application that removes corrupt or troublesome font cache files. I created this application as a tool for my personal use at the office, and has become very useful for me. To grant individual non-admin users the ability to remove font cache files, without my involvement--is HUGE! Not to mention intelligent application quitting, plus a GUARANTEED reboot, makes my life easier. FontNuke removes system font caches, Adobe font caches (*.lst), Microsoft Office font caches, and now also (as of version 1.0.6) QuarkXPress 6.x/7.x font cache files. Not to mention it's free.

http://www.jamapi.com/pr/fn/faq.html