Also try Seashore, based on Gimp, but smaller and simpler.

Gimp.org now has a native Mac application called Gimp.app that doesn't require X11.

After being told for 6 months that there was an update I finally see a v2.6.9 download for OS X.
http://gimp.lisanet.de/Website/Download.html

I am running v2.6.8, and AppFresh says I'm out of date and should upgrade ... to v2.6.8. ?

For everyday use, try Livequartz (http://osx.iusethis.com/app/livequartz).

I wish for an up to date Mac-native port, but I love it regardless.

Gimp has been a personal favorite of mine for a while now. There are almost no Gimp bugs on my Mac, plus is surprisingly light on system resources.

Gimp, Inkscape, and Audacity are a magic 3 for me. These raster graphics, vector graphics, and sound editing apps are the best of their kinds.

I've just installed the package from http://darwingimp.sourceforge.net

Works great! better than Gimp.app native build IMHO that looks somewhat clumsy.

Gimp along with Inkscape are great apps... I really hope someday GTK+ gets a proper OSX port to run them without X11.

Gimp is so awsome!!! It's almost as good as photoshop!! Get it.

Check the Gimp vs Gimp.app debate at http://osx.iusethis.com/app/gimpapp