Palm Desktop 4.2.1 synchronizes with Palm Z22, Palm TX, Treo 600, Treo 650, LifeDrive, Tungsten series, Zire series, i700 series, Palm m500 series, Palm m100 series, Palm VII series, Palm V series, Palm III series and PalmPilot mobile devices.

Palm® Desktop 4.2.1 synchronizes with Palm Z22, Palm TX, Treo 600, Treo 650, LifeDrive, Tungsten™ series, Zire™ series, i700 series, Palm m500 series, Palm m100 series, Palm VII series, Palm V series, Palm III series and PalmPilot mobile devices.