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SuperDuper!

SuperDuper can make a full backup, or "clone" — in moments, you can completely duplicate your boot drive to another drive, partition, or image file.
DEVONagent

Most complete academic and research search engine on the market.
DEVONthink Pro

DEVONthink is the solution for the digital age, the one database for all your documents. And it's flexible. It adapts to your personal needs. Use it as your document repository, your filing cabinet, your e-mail archive or your project organizer.

Contrast with DEVONthink Personal edition at http://www.devon-technologies.com/products/devonthink/comparison.html